Beilstein J. Org. Chem.2021,17, 866–872, doi:10.3762/bjoc.17.72
reactivities. The method using V-40 as an initiator is successfully investigated for the regio- and stereoselectivephosphinylphosphination of terminal alkynes giving the corresponding trans-isomers of 1-diphenylphosphinyl-2-diphenylthiophosphinyl-1-alkenes in good yields. The protocol can be applied to a wide
variety of terminal alkynes including both alkyl- and arylalkynes.
Keywords: (E)-1,2-bis(diphenylphosphino)ethylene derivative; radical addition; stereoselectivephosphinylphosphination; terminal alkyne; tetraphenyldiphosphine monoxide; Introduction
Organophosphorus compounds are an essential class of
A1. Radical A1 is captured by Ph2P(O)PPh2 to provide A2, regio- and stereoselectively [62].
Conclusion
In conclusion, a highly regio- and stereoselectivephosphinylphosphination of alkynes with Ph2P(O)PPh2 has been successfully developed. The radical initiator V-40 can be used to selectively generate
PDF
Graphical Abstract
Scheme 1:
Radical addition of Ph2PPPh2 and Ph2P(X)PPh2 to unsaturated C–C bonds.